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KMID : 0380219940270060488
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Journal of Biochemistry and Molecular Biology
1994 Volume.27 No. 6 p.488 ~ p.492
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Binding of Fibrinogen to Specific Receptors on Rat Peritoneal Macrophages
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Abstract
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Abstract:
@EN Binding of fibrinogen to specific receptors on rat peritineal macropahages was characterized. Fibrinogen receptors on rat peritoneal macrophages bind the fragment D domains of fibrinogen molecules, suggesting possible involvement of Mac-1 in
fibrinogen binding. Receptor-fragment D interaction was reversible and reached equilibrium after 60 min incubation at 4℃. Scatchared analysis of fragment D binding indicated a single class of receptors, a binding dissociation constant of 3.8
μM,
approximately 9.0×10E5 receptors per cell.
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